Jazz and Heroin Post-War America free essay sample

Post-war America, Jazz and Heroin by Gang Longer and James Baldwin Sonnys Blues Life after the Second World War changed for many, including the previously jolly jazzmen in Harlem. Whether through conspiracy, a search to remedy the anxieties of a struggling for image musician, or Just something that was pressed as a requirement to belong, heroin certainly made its bleak presence known. Trumpeter Red Rodney once said, Heroin became the thing that made us different from the rest f the world. It was the thing that gave us membership in a unique club. The conspiracy theory that some believe was planned to devastate Harems black inhabitants does seem to have some clout. Female Jazz musician Billie Holiday was one who may have fell Victim to this scheme. She was arrested in 1947 for narcotics charges, deliberately targeted for the such. Colonel White, a narcotics agent, we wanted to get some publicity [The Idea of arresting her was] a sudden inspiration to polish her off, to kick her over. We will write a custom essay sample on Jazz and Heroin: Post-War America or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Her arresting officer Jimmy Fletcher also coasted that he was carrying over six pounds of heroin at one time, assuming used to supply his informants. Post WI America appeared to have not been changed by way of the democratic freedoms won in Europe. Black Jazz musicians of this time were still singled out, denied integration with the rest of the population. They were forced to use staff lifts and back stairs at venues. They were made to stay in black only hotel rooms. And in some areas, they were even barred from eating In most restaurants. These young, lonely, unrecognized musicians tried to bond with one another to blot out the dismal oral around them; In an effort to find positively and acceptance, play together, and Inspire confidence, they were exposed to heroin.Atone time, Jazz great Males Davis was even a pusher, helping expose others to heroin, possibly wrecking their lives. One of those exposed was Count Basiss piano player Carl Drunkard, whom after being teased about being a square, tried heroin with Davis in 1952. Drunkard later commented, Miles Davis put that needle in my arm and helped me wreck my life. Drunkards wrecked, junkie lifestyle was also experienced by the likes of Charlie Parker, Fats Innovator, Chest Baker, and Bill Evans. Sonny, our young, almost lost, seemingly repressed subject in James Baldwin Sonnys Blues is a picture perfect example of all of this.Growing up in post-war Harlem, a young black man, with Jazz in his heart, Sonny fell victim to the seemingly unavoidable heroin-Junkie lifestyle. On the path of trying to follow the music of his heart, he gets twisted up with the drug, and Like Billie Holiday, gets arrested for such. And Like society at the time, even Sonny older brother Is one to oppress him, saying, Well, you may think its funny now, baby, but its not going to be so funny when you wrought the lives lived and manifeste d throughout this era, the blues come to surface.

Violence in Politics

Violence in Politics VIOLENCE IN POLITICSPolitics is a wide topic that includes lots of points but there is not a cleardefinition of politics, it is known that politics is present in all social relations no matter how small the group or the society. Politics might best be characterized as the constrained use of social power. Politics occurs where there is power relationship. The concept of power lies beneath politics. Human beings have the urge to gain power. They seek to be more and more powerful. This turns out to be a competition or a rivalry. Therefore, naturally in this competitive arena violence is felt and it is used as a means. Until today all of the civilizations and states have had violent memories, a war or a struggle, fight, revolt, etc. In the political framework, violence is the illegitimate use of power.Furthermore, Machiavelli transformed the meaning of politics. He statedthat the goal of politics is the pursuit of power.Adolf Hitler in Yugoslavia.According to him, the most important elem ents of politics are the rule of law. So far Machiavelli's ideas have aroused arguments and they are criticized. Many people still believe in his ideas and apply them as the basis for their study of modern political science. The influential political theorist Thomas Hobbes author of Leviathan strongly echoes Machiavelli's conviction that human beings are naturally wicked and require strong government to keep them from harming each other. On the other hand, as time moved on, many different types of political systems, such as fascism, democracy, communism, socialism and etc. sprung up. Violence in politics have occurred more in authoritarian regimes.The subject of violence in politics is a debatable issue; there can be many different ideas and opinions. Moreover, other than Hobbes, Machiavelli also influenced the cruel dictators. Mussolini and Adolf Hitler...

American Medical System (Is or not) broken Essay

American Medical System (Is or not) broken - Essay Example When all these aspects are put together, the American health system is deemed broken. This paper is going to give its focus on the broken American health care system. Furthermore, this paper will highlight the reasons behind having a broken health care system in the United States. In this paper, I ask; why is the American health care system broken? Reasons behind the American Broken Health Care System The broken American health care system can be attributed to various reasons. It is apparent that the American health care system is a complete paradox. This is because in regards to technology in medicine as well as the disease scientific understanding, the United States is a leader. Doctors in America are the best paid in the world. Despite all these privileges, the Americans are still not the beneficiaries (Gumbel). Gumbel continues to argue that the healthcare system is run by insurance companies that are profit-propelled thus making the system be inefficient and more expensive, besi des being dehumanizing. America’s expenditure on healthcare is two and a half times that of Britain, and twice as much as that of France. However, the health care system is on a meltdown in almost every key indicator in public health sector, high infant mortality rate when compared to other developed countries like Britain. There has been no serious debate on healthcare system in America since 1994 when Bill Clinton was the president and his wife Hillary Clinton failed in her attempts to overhaul the health system. About 45 million American citizens are not insured (Garson). This number includes 10 million children (Gumbel). Gumbel continues to remark that the growing numbers of uninsured is unacceptable in any civilized society, more so not in America. Analysts had predicted that the American health care system would be broken, come the year 2011, and the government would have taken measures to avert the situation before it happens. For instance, Bolen, a consumer advocate, had remarked in 2004 that everybody was aware that the U.S Medicare system would experience a meltdown in 2011. According to him, the healthcare care system was going to be unaffordable to most Americans. Bill Frist, the majority leader of the senate and a heart specialist physician, gives scary Statistics on the American health care system. The statistic show that America spends about 15% of its overall income on health issues. This is higher than other developed nations. In this regard, when broken down, America spends approximately $5,540 annually on every man, woman and child (Broder A24). Similarly, health care costs are experiencing four times increase when compared to wages. Broder predicted that in 2006, the cost of health care coverage sponsored by the employers would be at $14,500 per family. However, the health stakeholders and the government did not do anything to prevent the situation from taking place. In 2003, the Census Bureau stated that about 44 million Americans w ere rendered without health insurance in 2002. Amazingly, the number of uninsured has been on the increase to approximately two million people every year. A consumer group known as Families USA reported that about 82 million Americans did not have health insurance cover in 2002/2003 period, most of them for a period not less than nine months (Broder A24). Furthermore, The American Journal of Medicine, as

Tylenol Ethical Behavior 1982 Essay Example | Topics and Well Written Essays - 500 words

Tylenol Ethical Behavior 1982 - Essay Example Tylenol had been the most profitable medicine for Johnson & Johnson and its contamination represented a big threat to the company and its goodwill in the market. The company’s market share fell drastically from 35% to a mere 8%. Thus, the company’s aim was to react in a way that does not damage its reputation. Following the announcement to stop consumption of the product was the announcement that the company had recalled its product completely from the market which resulted in an immediate loss of $100 million (Suder, 2006). The important point to note here is that, although the company wasn’t responsible for the alteration in the product, it assumed the ethical responsibility at the cost of its profits. By demonstrating that the company genuinely cared for the soceity’s safety, Tylenol got sympathy vote from customers who started realizing the fact that Tylenol had been a victim of a criminal act ( done by somebody else) and that the company was innocent (Suder, 2006). Additionally, the company established repute and strong links with the FBI, Police and the administration of the Food and Drug department (Kaplan, 1994). Through this the company hoped to gain the confidence of these groups along with searching for the individuals behind the contamination. Furthermore, it devoted heavy sums of money to the media and advertising agencies in order to inform the public about stopping the use of Tylenol and spreading this awareness amongst the masses (Kaplan, 1994). They went to the extent of using â€Å"1-800† hotline to deliver the message across the country and also used pre-recorded messages to inform news agencies about the latest developments with respect to the crisis (Cutlip, Center, & Broom, 1999). The company also ensured that all its press conferences were aired on national television (Kaplan, 1994). This was, however, a short term

Business Project Management Essay Example | Topics and Well Written Essays - 3500 words

Business Project Management - Essay Example The researcher states that before initializing a project, project manager and team must be sure about the structure of the host firm because it influences their project and the operations they seek to perform. In addition, the culture of an organization is composed of certain attributes such as values, attitudes, viewpoints and behaviors of its staff members. In addition, it demonstrates the established principles and values of the organization, infusing all the activities which a corporation performs. In simple words, it can make a project a success or a failure. However, the perfect organizational culture is that in which projects are well thought-out in strategic management and are executed to promote and support a firm’s corporate strategy and corporate goals. As a result, top management pays more attention to them and assigns more and more organization’s resources to allow them to be successful. Here strategic management is the discipline of building, implementing, and assessing cross-functional decisions that facilitate a corporation to attain its goals. Moreover, each corporation has its own model organizational culture, operating systems and inside and outside resources to attain this. In addition, at the present it is necessary for the project managers to be familiar with the cultural, organizational and social environments adjacent the project. It could be done by recognizing the stakeholders and their capability to have an effect on the project. Thus, it could lead towards the likelihood of influencing project surroundings in an optimistic manner. Therefore, the any kind of risks could be considerably diminished; however failure to adopt such a way could unavoidably lead to a less than acceptable ending. In addition, the successful project managers would be familiar with the importance to put some effort in changing or improving the organizational culture for the benefit of the project stakeholders. In this scenario, it is the responsib ility of every team member of a project, undeniably every employee of the organization, needs to be influenced to express the attitude that, just as they are stakeholders, as well as every other project stakeholder is also vital (Wideman, 2001). Moreover, the organization's culture plays a significant role in success rate of projects. Take into account that this is about projects all throughout a corporation, not just about one specific project. In addition, the culture of a host organization plays possibly the major role in whether their organization is flourishing in running projects. On the other hand, if a supplier firm faces challenges running projects productively with the host firm, they cannot blame the project managers. In fact, they are struggling surrounded by a culture that is not in support of their struggle. Thus, it is essential for the project manager as well as the top management of the supplier firm to identify and assess the culture of the host organization. Until they are

Loss of Brain Nerve Cells in Alzheimers Disease

Loss of Brain Nerve Cells in Alzheimers Disease Fig-6: Showing neuronal death due to inflammation and oxidative stress. Adenosine Deaminase (ADA), and Neuropsychiatric Disorders:- Adenosine is a neuromodulator of brain function that is uniquely positioned to integrate excitatory and inhibitory neurotransmission and neuroprotective actions in pathological conditions. The understanding of adenosine production and release in the brain is therefore of fundamental importance and has been extensively studied (ADA-8). Adenosine metabolism in the brain is very important, and its dysregulation has been implicated in pathophysiology of several neuropsychiatric disorders, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin and acetylcholine, decreases neuronal activity by pos-synaptic hyperpolarization and inhibits dopaminergic activity. Adenosine deaminase participates in purine metabolism by converting adenosine into inosine (ADA-7). (The production and metabolism of adenosine is given in the Fig.7) Adenosine deaminase (ADA, adenosine aminohydrolase, EC 3.5.4.4), an enzyme involved in the metabolism of purine nucleosides, catalyses the irreversible hydrolytic deamination of adenosine (Ado) and 2 ´-deoxyadenosine (2 ´-dAdo) to inosine and 2 ´- deoxyinosine, respectively. The enzyme is widely distributed in vertebrate tissues and plays a critical role in a number of physiological systems. In nature, several isoforms of ADA are known that differ by molecular mass, kinetic properties and tissue distribution (ADA-2). It plays a role in the development and functioning of T lymphomonocytes. Levels of this enzyme increase during the mitogenic and antigenic response of lymphocytes, whereas ADA inhibitors limited the blastogenesis of lymphocytes; thus, ADA levels are higher in T cells than in B lymphocytes. ADA was previously recognized as a cytosolic enzyme; however, it is currently known to be present at the surfaces of cells, in particular T lymphocytes, to interact with some membrane proteins, including CD-26/DPP IV, and is considered an ecto-enzyme. This co-localization of DPP IV/CD-26 and ADA at T cells is important for the activation of T cells because the interaction of ADA and CD-26 at the T cells results in co-stimulatory signs responsible for the activation of the T cell receptor (ada ). Long considered to be an immune-privileged site because of the presence of the blood-brain-barrier (BBB) and the lack of a lymphatic system, it is now well-established that the brain is fully capable of mounting inflammatory responses in response to invading pathogens, trauma, or ischemic events (G-17). Fig. 7 Pathways of adenosine production, metabolism and transport, with indications of the sites of action of various enzyme inhibitors. Abbreviations are as follows: ADA, adenosine deaminase; AK, adenosine kinase; AOPCP, a,b-methylene ADP; DCF, deoxycoformycin; EHNA, erythro-9-(2-hydroxy-3-nonyl)adenosine; es, equilibrativesensitive nucleoside transporters; ei, equilibrative- insensitive nucleoside transporters; 5-IT, 5-iodotubercidin; NBMPR, nitrobenzylthioinosine; PDE, cAMP phosphodiesterase; SAH, S-adenosyl homocysteine. Activation of oligodendrocytes results in secretion of inflammatory molecules, such as nitric oxide (NO), cytokines, and prostaglandins and most  notably in upregulation of several chondroitin sulfate proteoglycans, including NG2, which contributes to the growth-inhibitory environment that prevents regeneration of axons in the injured CNS. In summary, in acute situations and when short lived, neuro-inflammatory mechanisms generally limit injury and promote healing; however, when neuro-inflammation becomes chronic it can damage viable host tissue, resulting in compromised neuronal survival and cognitive impairment. For these reasons, inflammation in the CNS has been appropriately described as a two-edged sword (G-17). Again Hcy activates cytokines and pro-inflammatory molecules, such as IL-1beta, IL-6, IL-12, IL-18, IL- 1 receptor antagonist, C-reactive protein, adhesion molecules (P-selectin, E-selectin, ICAM-1), and metalloproteinases (MMP-9). In addition, Hcy up-regulates reactive oxygen species, leading to activation of NF-kappa B, the pro-inflammatory nuclear regulatory molecule (G-3). On the other hand, neuropsychiatric disorders have been shown to be accompanied with some immune-inflammatory alterations. In this regard in order to make a contribution to the understanding of the ongoing immune disturbance in neuropsychiatric disorders, serum ADA activity was determined in neuropsychiatric patients and compared with healthy controls. Intracellular and extracellular levels of adenosine are tightly controlled by specific nucleoside transporters and several important enzymes, which include adenosine deaminase (ADA) and 5’-nucleotidase (5’-NT) (ADA-4). ADA activity is known to be increased in inflammatory diseases characterized by T-cell activation and proliferation. Therefore, ADA is considered a marker of T-cell activation. In addition, overproduction of reactive oxygen species (ROS) including hydrogen peroxide (H2O2), superoxide anion (Oà ¢- _ 2); nitric oxide (NOà ¢- ) and singlet oxygen (1O2) creates a condition known as oxidative stress, resulting in the amplification of the inflammatory response (ADA-6). Studies related to ADA levels in neuropsychiatric patients are virtually non-existent. ADA and schizophrenia Adenosine may play a role in the pathophysiology of schizophrenia, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin etc. Dutra GD et al (2009) showed that decreased ADA activity in schizophrenic patients than in control subjects (ADA-7). Brunstein MG et al (2007) reported that the schizophrenic patients treated either with typical antipsychotics or clozapine showed increased serum ADA activity compared to controls (ada-b sub 14). ADA and Depression Elgun et al (1999b) reported that decrease ADA activity in patients with depression compared with controls, might reflect the impaired immune system in depression (A sub). Mackiewicz et al (2006) showed that ADA levels did not change with age in rats (A sub). Herken H et al (2007) showed that ADA levels of the patients were significantly higher than the controls (abstract ref). An increasing body of evidence implicates both brain inflammation and oxidative stress in the pathogenesis of Alzheimers disease (A-9). Inflammation is a cause, contributor, or secondary phenomenon in the disorder inflammatory pathways are altered in the periphery in AD, together with evidence that increased peripheral inflammation leads to more neurodegeneration and accelerated disease progression in animal models. Antioxidants defense:- Humans have evolved a highly complicated antioxidant defense system to combat the damaging effects of free radicals. Under physiological conditions, overproduction of ROS and RNS and their neutralization is prevented by the activity of endogenous anti-oxidative defense system (AOS). Antioxidants are a broad group of compounds which constitute the first line of defense against free radical damage thus are essential for maintaining optimum health and well-being. They are protective agents, capable of stabilizing or deactivating free radicals before they attack cells. Being beneficial compounds, they control free radical formation naturally and help organisms to deal with oxidative stress caused by free radicals (antiox 4) (Fig. 8). Antioxidant system encloses enzymes like superoxide dismutase; catalase, glutathione peroxidase, and other antioxidant-regenerating enzymes such as gluthatione reductase; dehydroascorbate reductase and glucose-6 phosphate dehydrogenase, that maintains reduced NADPH; hydrophilic scavengers like urate, ascorbate, gluthatione, flavonoids; lipophilic scavengers, like tocopherols, carotenoids and ubiquinone. The great majority of antioxidants are supplied with the diet and includes polyphenols, lipoic and ascorbic acid, carotenoids, lycopene, quercetine, genstein, ellagic acid, ubiquinone and indole-3 carbinole. In fact, in the biological systems, the normal processes of oxidation produces highly reactive free radicals and each of this administered compounds is involved in the physiological redox balance preventing damage to the tissues (antioxi 3). Enzymatic Antioxidants An important part of the intracellular antioxidant defense systems are antioxidant enzymes such as superoxide dismutase, catalase and peroxidases. Superoxide dismutase (SOD) SOD is found abundantly in many organisms, from microorganisms to plant and animals, since superoxide radicals (O2−†¢) are toxic to living cells, oxidizing and degrading biologically important molecules, such as lipids and proteins. The role of SOD is to protect aerobic cells against O2−†¢ action. It catalyzes O2−†¢ dismutation reaction into H2O2 and O2−†¢. There are three known types of SOD: two copper-zinc containing SOD (CuZn-SOD), one in cytosol and one bound to the vascular endothelium ( also called â€Å"extracellular SOD† (ECSOD)) and a manganese containing SOD (MnSOD), which is localized in the mitochondrial matrix (antio-4). This enzyme specifically catalyzes the dismutation of O2−†¢ anion into H2O2 and O2−†¢ in a pH-independent medium (5–9.5). Manganese SOD is the mitochondrial form of this dismutase. Its active site contains manganese and reduces the O2−†¢ generated during the ETC. T he amount of MnSOD inside the cell varies according to the number of mitochondria found in each cell type. This enzyme has antitumor activity. Extracellular SOD also contains copper and zinc in its structure and is the main extracellular SOD. It is synthesized inside the cells and secreted into the extracellular matrix (G-66, G-71, SOD-1). Fig. 8- Mechanism of action of antioxidants Catalase (CAT) Catalase is an enzyme that reacts very effectively with H2O2 to form water and molecular oxygen and with H donors (methanol, ethanol, formic acid, or phenols) with peroxidase activity. Catalase protects cells against H2O2 generated inside them. Although CAT is not essential to some cell types under normal conditions, it has an important role in the acquisition of tolerance to ONS in cellular adaptive response (G-10). Glutathione peroxidase (GPx) and Glutathione Reductase GPx is an enzyme that contains a single selenocysteine (Sec) residue in each of four identical subunits, which are essential to the enzyme’s activity. Humans have four different GPx types: (1) a classic cytosolic form; (2) a membrane-associated GPx phospholipids, (3) another cytoplasmic enzyme, gastrointestinal GPx; and (4) an extracellular type. All GPx enzymes are known to add two electrons to reduce peroxides by selenols forming (Se-OH). GPx antioxidant properties allow them to eliminate peroxides as potential substrates for Fenton’s reaction. Glutathione peroxidase works together with glutathione tripeptide (GSH), which is present in cells in high (micromolar) concentrations. The substrate for the GPx catalytic reaction is H2O2 or organic peroxide ROOH. Glutathione peroxidase catalyzes hydroperoxide reduction using GSH, thus protecting mammalian cells against oxidative damage. Glutathione metabolism is one of the most important antioxidant defense mechanisms (G-10). Together with classic H2O2-removing enzymes (CAT and GSH-Px), the enzyme thioredoxin reductase (TrxR) is a seleno-flavoprotein which forms the thioredoxin system together with the protein thioredoxin (Trx) and NADPH. This is an effective system to reduce proteins in disulfide form and it also participates actively in the removal of H2O2 and other peroxides (G-57). 4) Thioredoxin reductase (TrxR) TrxR catalyzes the reduction of Trx especially, but in humans it can also reduce other substrates, such as vitamin C. This reductase also catalyzes the reduction of disulfide proteins and it is involved in countless vital processes, such as DNA synthesis and the regulation of apoptosis. Additionally, this system also donates electrons during DNA synthesis, and NADPH and human TrxR by themselves or with Trx are efficient electron donors to this human plasma peroxidase, which allows this enzyme to reduce hydroperoxides even when there are low levels of GSH available (G-52). There are three identified TrxR isoenzymes: cytosolic (TrxR-1), mitochondrial (TrxR-2), and a third isoenzyme which has been isolated from the mitochondrion of rat testes (TrxR-3). TrxR-1 has wide substrate specificity, since it is responsible for reducing not only Trx but also hydroperozides, lipoic acid, ubiquinone, and dehydroascorbate. Thus, the Trx system is regarded as having a crucial role maintaining a cell’s redox state. It may also have a role in the system which regulates the expression of redox-sensitive genes through the activation of transcription factors (G-58). Non-enzymatic Antioxidants Vitamin E (ÃŽ ±-tocopherol) The lipid-soluble antioxidant vitamin E is localized in the cell membrane and has been targeted for its relation to atherosclerosis and vascular function. Decreased concentration vitamin E (ÃŽ ±-tocopherol) scavenges the chain-carrying peroxyl radicals rapidly and interrupts the chain propagation. During this reaction, vitamin E becomes a free radical called tocopheryl, which is less reactive than the lipid radical and migrates to the surface of the membrane to be transformed again into tocopherol through the action of ascorbic acid (G-72) (Fig-9). However, in elevated concentrations the tocopheryl radical may act as pro-oxidant. On the other hand, ÃŽ ²-carotene is a hydrophilic precursor of vitamin A and large concentrations accumulate in the membranes of certain tissues. Its antioxidant activity is related to the removal of O2−†¢ and free radicals formed during lipid peroxidation. This activity is due to its conjugated double-bonded structure that can dislocate unpaired electrons, which enables ÃŽ ²-carotene to physically quench singlet oxygen without degradation (G-65). Vitamin C (ascorbic acid) Vitamin C is a hydrosoluble antioxidant, which facilitates its diffusion into intra- and extracellular matrices. Its antioxidant potential is related to direct removal of O2−†¢ and HO†¢. Furthermore, it contributes to regenerating oxidized vitamin E; however, vitamin C also has pro-oxidant activity. It may be the one compound, in addition to HO†¢, that can convert Fe3+ into Fe2+, which then reacts with H2O2 to form OH. Vitamin C is a water-soluble vitamin that participates in a large number of cell functions (antio 5). All

Tay-Sachs :: science

Tay-Sachs The genetic disorder I have looked at in this scientific statement is Tay-Sachs disease or TSD, a serious, inherited fatal brain disorder. The disease is named after Warren Tay, a British ophthalmologist who first described the disease in 1881 and a New York neurologist, Bernard Sachs; who first described the cellular changes and the genetic nature of the disease in 1887. This rare hereditary disease is caused by a genetic mutation that leaves the body unable to produce an enzyme; a protein that speeds up the rate at which chemical reactions take place within the body. The enzyme is necessary for nerve cells to metabolise fat, (allow for chemical reactions to take place within the cell) . The enzyme involved in TSD is known as hexosaminidase A. its absence allows a lipid called GM2 ganglioside to build up in the brain, destroying the nerve cells. The location of the gene HEXA that causes the genetic disorder is 15q23-q24. Tay-Sachs is an autosomal recessive disorder. My research indicates that a person must have two carriers as parents for the disease to occur. Carriers, people with only one gene for the disorder are physically unaffected due to it being recessive. When both parents are carriers, each child has a 25% or  ¼ chance of obtaining the disease. If only one parent is a carrier, there is no chance that the child will get the disease, but there is a 50% chance that the child will be a carrier. My extensive research has concluded that the symptoms of the disease are: ï  ¶ Blindness ï  ¶ Dementia ï  ¶ Deafness ï  ¶ Seizures ï  ¶ Paralysis All these symptoms appear during the first six months of life following the case studies data. The disease progresses rapidly, usually killing affected children by age three. As the damage to the nervous system progresses, an inability to swallow, difficulty in breathing and mental retardation develop. In late-onset TSD, which occurs in people who have a genetic mutation (A permanent change in the DNA sequence due to an insertion, deletion or an alteration) that is similar to that of TSD that occurs in young children. Some production of the missing enzyme occurs and life expectancy does not seem to be affected according to my research. Medical treatment is focused mainly on managing the symptoms of late onset TSD, Anticonvulsants can be prescribed to patients with seizures and antidepressants can be used as to help with psychiatric symptoms.

In the name of the father Essay

Often a film conveys a message about a character through various film techniques. This is true in the film â€Å"In The Name of the Father†. This story is mainly about a young man who is arrested for a crime he did not commit and how a relationship between father and son deepens throughout the tragedy. The main character, Gerry Conlon, is first portrayed to the viewer as an unruly rebel but is later developed into a more docile and compliant character. The director, Jim Sheridon, uses film techniques such as costume design, dialogue and extended metaphors to convey the development of Gerry as a character. 1st paragraph: -1st time we see gerry, scruffy, uncut -costume design – baggy jeans, long hair, dirty appearance -gives idea that gerry doesn’t care about his appearance or what people think of him -as film progresses he sharpens up appearance -combed pulled back hair 2nd: -change also shown through dialogue -lawyer asks him if he is scared of the court: -he replies â€Å"i just don’t want to be humiliated again† -this brief piece of dialogue shows that he has now changed and does care what others think of him -helps viewer understand how desperate an innocent man can be in the fight for justice 3rd: -use of extended metaphor -viewer sees lawyer gareth pierce driving through a long tunnel while listening to gerrys story -this could be viewed as an extended metaphor for the long dark road gerry has gone down while fighting the legal system -as the story draws to a conclusion she reaches the end of the tunnel, or the ‘light at the end of the tunnel’ -could refer to the point in the story where gerry and the others are finally set free. Read more:  My Father Goes to Court by Carlos Bulosan

Language And Communication Children And Young People Essays

Language And Communication Children And Young People Essays Language And Communication Children And Young People Essay Language And Communication Children And Young People Essay The cardinal involvement of this essay is to measure the function of drama in relation to linguistic communication and communicating development. Developmental psychological science and theories of drama are the chief beginnings of researching and explicating this alone interrelatedness, because they offer critical information about human behaviour. For this ground several developmental theories have been developed by many scientists such as Jean Piaget, Lev Vygotsky, Sigmunt Freud, Albert Bandura and other modern-day scientists, who managed to clear up the facets of kid development from different positions. Initially, this essay illustrates the importance of drama by depicting its classs. Play theories are briefly demonstrated and divided into classical and modern-day 1s. Thereafter, it mentions the features of linguistic communication through the theories of two extremely well-thought-of scientists, Lev Vygotsky and Jean Piaget, in order to understand the correlativity between linguistic communication and drama development. It besides illustrates the being of nine basic communicating accomplishments and why non-verbal and verbal communicating is so of import. Furthermore, this essay analyzes research which explains the direct relation between drama, linguistic communication and communicating. Through elaborate mentions, the thought that the function of drama is outstanding in a kid s development is supported. Next it illustrates the importance of finger, mummer and rime drama to explicate that even the most common games possess a important function in linguistic communication and commu nicating development. Last but non least, it analyzes how play reinforces the literacy development and eventually demonstrates the sentiment of the author. The Importance of Play Arguably, drama is a critical portion of kids s development which has many deductions in their lives. Despite the trouble of mentioning to a normally accepted definition, drama is a critical portion of the developing kid ( Sheridan A ; Howard A ; Aldelson, 2011 ) . It is a cardinal action which occurs throughout kids s lives and is divided into two classs, free drama and structured drama. To be exact, free drama is an action where the kid can take the regulations and the signifier of drama, without the engagement and the battle of an grownup. Hence, the kid becomes the leader of drama ( Tassoni A ; Hucker, 2000 ) . Furthermore, many research workers have claimed that free drama offers more educational chances to kids. Whereas structured drama is defined as an action which is directed by grownups and limits kids s acquisition potencies. Adults are supporters and possess a primary function in this type of drama. For this ground, Thomas, Howard and Miles proved by a survey they conducted, that free drama, in other words playful mode drama, is capable of furthering kids s ability to larn. They province that through this manner kids s communicating is benefited, because gaiety creates the ability to heighten assorted types of behaviours. As a consequence, educational scenes use the playful method to further kids s linguistic communication and communicating development ( McInnes A ; Howard A ; Miles A ; Crowley, 2009 ) . It is of importance to advert that there are drama theories which are separated into two classs, classical and modern theories of drama. In peculiar, classical theories consist of the Surplus Energy Theory, Recreational or Relaxation Theory, Pre-exercise Theory and the Recapitulation Theory of drama ( Sheridan A ; Howard A ; Aldelson, 2011 A ; Stagnitti, 2004 A ; Tassoni A ; Hucker, 2000 ) . Modern theories concluded by the Arousal Modulation Theories of Play, the Psychodynamic Theories of Play, the Cognitive Developmental Theories of Play and the Sociocultural theories of Play. The last class is divided into two sub-categories which are the Play as Socialization and the Metacommunicative Theory ( Stagnitti, 2004 ) . Furthermore, there are five types of drama, which are cited as physical drama, drama with objects, symbolic drama, socio-dramatic/pretence drama and games with regulations ( Whitebread, 2012 ) . The above five types of drama aid kids to spread out their abilities non merely in the linguistic communication and communicating sphere, but besides in the physical, cognitive, societal and emotional sphere ( Sheridan A ; Howard A ; Aldelson, 2011 ) . Harmonizing to the changeless development of linguistic communication and communicating, drama and its benefits in this sphere must be analyzed in deepness, in order to measure kids s developmental potencies through drama. Language and Communication Language is a strong communicating tool ( Moyles, 1989 ) which fosters kids s abilities. Through linguistic communication we can populate the yesteryear once more, measure the hereafter and utilize this critical tool when we face complex state of affairss ( Crain, 2000 ) . Besides, many developmental theoreticians have tried to explicate, how kids adopt cardinal abilities as they grow up and some of them, hold given particular accent to the linguistic communication and communicating development and how it is related to play. They have evaluated kids s development from birth to maturity. Vygotsky, who was characterized as the Mozart of Psychology ( Gray A ; MacBlain, 2012, p.85 ) , claimed in his societal constructivism theory, that linguistic communication is the cultural tool which facilitates the procedures of thought and acquisition. It was his house belief that kids must grok linguistic communication, in order to interact in the society. Hence, harmonizing to Vygotsky, drama and linguistic communication are interrelated ( Moyles, 2005 ) . Due to the fact that through drama kids maestro communicating accomplishments, they interpret the usage of objects and copy the attitudes and the wonts of grownups ( Gray A ; MacBlain, 2012 ) . In add-on, he stated that kids gain cognition when they participate in societal communicating and accordingly, they adopt new significances. Therefore, harmonizing to Vygotsky, kids act in the zone of proximal development ( Whitebread, 1996 ) , which means that every kid has limited possible when carry throughing an activity but he ca n spread out his accomplishments with suited aid ( Lindon, 2001 ) . However, another respected scientist Piaget did non put accent, as Vygotsky did, on the importance of linguistic communication during kids s development. Piaget stated that linguistic communication mechanism is used by the immature kid merely to show some basic satisfactions and non to further more complex maps such as idea and logic ( Gray A ; MacBlain, 2012 ) . Furthermore, Piaget s sentiments did non advance kids s abilities ; alternatively he undervalued them, by using activities that were excessively complex for kids competency ( Whitebread, 1996 ) . On the reverse, some scientists argue that kids s idea, starts to work logically as they learn how to utilize linguistic communication. This happens because linguistic communication accomplishments are hard for kids to absorb, but when this bit by bit occurs, logic develops ( Crain, 2000 ) . Nevertheless, Piaget did non back up the above impression by adverting that logic derives from actions ( Gray A ; MacBlain, 2012 ) . On the evidences that linguistic communication is an built-in portion of communicating, it is of import to nail some of the accomplishments that kids develop in this sphere. In other words there are nine basic communicating accomplishments. Initially, kids learn to bespeak support, to bespeak aid, to accept and reject offers. Furthermore, they respond to the order wait or no , they respond to waies, follow a agenda and eventually they are able to do a passage from one topographic point to another ( Frost A ; Bondy, 2002 ) . For case, when kids pretend to be a patient in a infirmary, they learn when they have to wait their bend in order to be examined by the physician and they give orders such as wait , stay , come . Communication is a complex map. Before the outgrowth of words, kids can pass on adequately before following linguistic communication production and linguistic communication comprehension ( Sheridan A ; Sharma A ; Cockerill, 2008 ) . The above facet describes the non-verbal communicating type which is really of import. Newborn babes communicate nonverbally to show their demands. Facial looks, organic structure linguistic communication, proto-sounds and perceptual experience of feelings are the properties of non-verbal communicating ( Whitehead, 1999 ) . Hence, adults start to pass on with kids ab initio nonverbally and finally verbally. Research proves that conversation between kids and grownups which contains a big figure of unfastened inquiries is indispensable because kids have the chance to react to talk linguistic communication. In other words, when kids feel that they are active participants in an adult-child conversation, they feel playful which is salient for the development of linguistic communication ( Howard A ; McInnes, forthcoming ) . Fostering Language and Communication Skills through Play To get down with, surveies have proved that there is a strong connexion between linguistic communication and drama. Research which was conducted in Japan in 1989, showed singular marks that drama and linguistic communication are strongly correlated. Specifically, the four kids who participated in this research were observed 20 times each in a free drama manner, where the grownups had a inactive function. The purpose of the survey was to analyse early linguistic communication development and drama development ( Ogura, 1991 ) . Therefore, six characteristics of linguistic communication were illustrated in order to analyse the findings better. These were the outgrowth of first words, calling words, vocabulary jets, word-chains, nonproductive two word vocalizations and the outgrowth of productive two-word vocalizations ( Ogura, 1991 p.278 ) . Furthermore, this research divided drama into 13 subcategories. The findings showed that kids managed to obtain the ability of calling words becaus e they had been involved in preverbal communicating. Besides, kids began to call objects when the conventional naming act class of drama appeared. Furthermore, words and sounds have a strong relationship with each other. It was proved that kids through the functional relational use drama and the container relational use drama, managed to follow the above of import map and the production of first words every bit good. Furthermore, it was stated that early linguistic communication development is related to subsitutional drama. Besides, this survey illustrated that the environment plays a major function in the development of symbolic drama. As a consequence, linguistic communication is influenced by societal interaction. Furthermore, kids s vocabulary jets appeared in subsitutional drama. Word-chains appeared when make-believe doll drama, subsitutional drama and feign other drama took topographic point during the observations. In add-on, the 5th linguistic communication class appeared with planned drama and combinative symbolic drama. The last linguistic communication class was related to planned drama ( Ogura, 1991 ) . Undoubtedly, this paper shows the alone interrelatedness between linguistic communication development and drama. Research workers evaluated the connexion between symbolic drama with drama stuffs and symbolic drama with drama state of affairs. First, during kids s drama with unstructured drama stuffs, they found that kids who are at the age of three to four could copy the activities of grownups. However, in structured drama kids were able non merely to copy but besides to prosecute somewhat in function drama. At the age of four to five kids s unstructured drama evolved and they started to show inquiries and thoughts with the mediate tool of spoken linguistic communication. On the contrary, in structured drama they used more conversation. This survey showed that in the first type of drama kids at the age of five to six used their organic structure linguistic communication and voice to clear up a state of affairs. Besides, both in structured and unstructured drama, kids preferred to play in groups of their ain gender. We can detect that structured stuffs are better for younger kids because they do non set restrictions on their thoughts while playing. In other words, younger kids need to heighten their expressive thoughts by playing with structured drama stuffs to be adequately prepared for school ( Umek A ; Musek, 2001 ) . At the same clip, symbolic drama related to play state of affairs showed that phonic imitation ( Umek A ; Musek, 2001, p.61 ) is promoted and that at the age of four kids use societal address. Furthermore, they use societal markers, in order to talk like grownups ( Ervin-Tripp, 1973 ) . Subsequently, at the age of five kids use metacommunication in their drama. Metacommunication is really of import because kids can discourse drama. They stop in order to negociate the following measure of the game. Indeed, it promotes duologue among equals. It is really of import because it can be used as scaffolding to kids s linguistic communication development ( Andersen, 2005 ) . Harmonizing to this survey, metacommunication degrees are higher when kids are older. Furthermore, the same survey proposes that it is better and more helpful for kids to play in assorted groups instead than in groups with members of their ain age. Hence, kids can play in the zone of proximal development. Therefore, they foster their linguistic communication and communicating accomplishments. Again, this survey shows us that drama which is dependent on stuffs or state of affairs is correlated with linguistic communication development. Apart from the above surveies there are drama activities which enhance linguistic communication and communicating accomplishments. For case, kids are benefited by mummer because they develop an alternate idea. This occurs by detecting assorted kids showing their ideas. Consequently, they can believe of more complex state of affairss and they are able to show their thoughts with enriched vocabulary. Furthermore, finger drama helps kids with the numeration procedure ( Woodard A ; Milch, 2012 ) . Furthermore, rimes can supply many chances for kids to heighten their linguistic communication accomplishments. Harmonizing to a survey, rime consciousness helps kids to acknowledge phonemes which are really of import for reading accomplishments. The sensitiveness to rime enables kids to group words together with the same spelling characteristics ( Bryant A ; MacLean A ; Bradley A ; Crossland, 1990 ) . Play Fosters Literacy Vygotsky evaluated the function of pretend drama in kids s development and he argued that literacy is enhanced by drama. He describes that kids ab initio act spontaneously when they play, and the procedure of larning happens with their will. On the contrary, when kids go to school they must alter their behaviours to a planned and a structured environment. Vygotsky stated that pretend drama is the of import mediate tool for kids to follow written linguistic communication and to win in school ( Roskos A ; Christie, 2007 ) . Furthermore, pulling is considered to be a necessary drama for kids. Research has shown that kids can spread out their graphic vocabularies and they can stand for their significances, which means that through pulling communicating is enhanced ( Whitebread, 2012 ) . Besides, Vygotsky s research has shown that drawings in early childhood are connected with the ability of authorship and spoken linguistic communication, which means that the significance of kids s drawings is non merely the drawing as a image but the drawing as an expressive tool of their ideas ( Roskos A ; Christie, 2007 ) . In decision, it is deserving adverting, that in kids s drama the repeat and the renaming of drama stuffs fosters the ability of the direct relation between words and the objects they portray. The above map is called metalinguistic consciousness and it has been proved that it is necessary for written linguistic communication ( Roskos A ; Christie, 2007 p.193 ) . Decisions It is clear, hence, that the above essay illustrates the direct correlativity between drama, linguistic communication and communicating. Despite the fact that it has been proved that drama fosters the acquisition procedure, there are still oppositions of this position, who province that formal acquisition schemes are better than playful attacks. However, this essay contradicts the impression of formal larning methods by back uping the theory, that play does heighten linguistic communication and communicating by mentioning equal bibliography to turn out it. Children can make high criterions in the learning procedure of linguistic communication because during drama they are motivated and are non possessed by the feeling of fright ( McInnes et al. , 2009 ) . To sum up, due to the fact that drama has been decreased in school scenes, it is outstanding to guarantee that drama must be in preschool and in the first school old ages of a kid, because a kid is ever above his mean age, above his day-to-day behaviour ; in drama it is as though he were a caput taller than himself ( Roskos A ; Christie, 2007, p.199 ) .

The Spider and the Fly Essay Example

The Spider and the Fly Essay Example The Spider and the Fly Paper The Spider and the Fly Paper Essay Topic: Poetry In the famous poem The Spider and the Fly written in 1829, Mary Howitt writes of a spider who cunningly persuades a fly to visit his parlor through flattery and carefully chosen words. The fly at first resists, but eventually falls prey to vanity, and, when the spider has disappeared, flutters Into the parlor, only to be pounced upon and devoured for dinner. On the literal level, the spider uses meiosis to tranquilize the flys fears of the web, and all its implications (flrst and foremost: inevitable doom). By simply referring to it as a parlour the spider is able to negate all the negative onnotations of a spiders web, and the actual ramifications of entering such a web: death. A web is where a spider kills and feasts upon its prey, but through meiosis the spider replaces web with parlour, which simply is a place while people drink- thereby not specifying who will be drinking (the spider) and what hell be drinking (the spiders blood). Understanding the cultural and historical context is the single most important factor in determining the underlying meaning of this poem. Critical analysis Seths poem Is In the form of a story narrative; a parable that seeks to teach as It peaks. The frog Is an unmusical fellow, who nevertheless sings through the night causing his neighbours a lot of discomfort. He refuses to be cowed by any form of restraint and remains the neighbourhood bully. When the nightingale astounds everybody with her beautiful voice, ther frog found himself jealous and upset with her presence and he set about systematically eliminating his rival through a sinister plot. Her realises that she has no notion of her abilities. He makes use of that. He makes her believe that he is a maestro and a music critic. He keeps putting her abilities down. He drives her relentlessly and makes money off her as her tutor as well as from people who wish to listen to her. Soon she breaks down and dies and the frog rules the roost again. The bog once again echoes with the unmusical croaks of the frog. The Spider and the Fly is a poem by Mary Howitt (1799-1888), published In 1829. The first line of the poem is Will you walk Into my parlor? said the Spider to the Fly. The story tells of a cunning Spider who ensnares a naive Fly through the use of seduction and flattery. The poem is a cautionary tale against those who use flattery and charm as a front for potential evil. the poem concerns a very eloquent spider trying to entire a beautiful fly into his manor. The artwork is very detailed and in a simple black and white scheme. The poem itself is very straightforward and the rhyming pattern is very catchy which. The conflict is between the Spider and the Fly but has a deeper understanding and moral to that. The moral of the tale is that not everyone who flatters and acts friendly really is. Sometimes the very worst things in ife lurk beneath pretty, flowery words. The spiders cunningness stands contrasted with the Innocence of the fly, but the spider succeeds only because the fly Is prone to flattery and Is gullible. Assay By shbhmasthana In the famous poem The Spider and the Fly written in 1829, Mary Howitt writes of a spider has disappeared, flutters into the parlor, only to be pounced upon and flys fears of the web, and all its implications (first and foremost: inevitable doom). By not specifying who will be drinking (the spider) and what hell be drinking (the Seths poem is in the form of a story narrative; a parable that seeks to teach as it speaks. The frog is an unmusical fellow, who nevertheless sings through the night everybody with her beautiful voice, ther frog found himself Jealous and upset with of the frog. The Spider and the Fly is a poem by Mary Howitt (1799-1888), published in 1829. The first line of the poem is Will you walk into my parlor? said the Spider to with the innocence of the fly, but the spider succeeds only because the fly is prone to flattery and is gullible.

Strategic Management Analysis - Based on case study Essay

Strategic Management Analysis - Based on case study - Essay Example Better Place opened its first car demonstration center in Israel back in February 2010. The opening of the demonstration center helped the company in showcasing its ambitious plan in challenging the status quo in the rigid and complex industry. The performance of the company has since been outstanding with the formation of partnerships and increased capital funding. Strategic purpose: Mission, Values and mission The mission of the company was to reduce and eventually eliminate oil dependence of the automobile industry. The company aims at reducing the associated health, political and environmental issues that arise from the dominance and ubiquity of internal combustion engine (ICE). The increasing number of vehicles around the globe that have high emission of carbon monoxide and hydrocarbons from the use of oil is responsible for the greenhouse gas emissions. With the growing ratio in the world populations as well as the demand for personal transportation, the environment and economi c sustainability of an ICE dominated transportation sector is highly likely to increase The company aims at attaining a widespread adoption of electric vehicles (EVs) by the creation of links between battery companies, car companies, utilities and consumers. The strategic objective of the company is to take over the market on product performance and delivery of quality and emission free cars to the consumers. This involves having a broader and deeper use of technological capabilities and they believe that the solution to electric cars does not lie in re-engineering the battery but in the re-engineering of the car. Stakeholder analysis Shareholders all those groups of individuals or individuals who depend on a given organization in order to fulfill their goals where the organization ends up benefiting. The main stakeholders of Better Place are the consumers, political groups, suppliers and competitors (Johnson, Whittington & Scholes 2011). Stakeholder management is very high in Bette r Place as they have been factored into the development of Electric Vehicles. For example, Shai Agassi the founder of Better Place believes that overcoming the problem of limited mobility is the only way that consumers would be enabled to adopt the Electric Vehicles (EVs) on a massive scale. The different stakeholders for Better Place influence each other in a positive way. The electric vehicle solution has made provisions and considerations of all the stakeholders. The political stakeholders include the state. For example, the State of Hawaii has launched a Clean Energy Initiative that is aimed at the development of clean energy alternatives by 2030. Adoption of EVs in the State would be the best clean energy alternative for people. This has had positive impacts on the consumers, suppliers and competitors. For the consumers, the move by the state will lead to the reduction of risks which results from carbon monoxide emissions and to enhance adaptability and flexibility. Maintenance costs of electric vehicles are much lower than the ICE vehicles for consumers. It is a social, economic and ethical responsibility for companies to produce and manufacture those cars that will not cause any environmental harm. Better Place owes this to its stakeholders hence the reason for the EVs. External environment analysis The macro-environment (Porter’s 5 forces analysis) Supplier power- There is few suppliers in the supply of electric vehicles around the globe. Better Place is a powerful supplier due to the

The Promised Land Essay Example | Topics and Well Written Essays - 1500 words

The Promised Land - Essay Example Deuteronomistic history reflects about Lord’s blessings and prosperity of the covenant on obeying laws and the Lord’s instructions; whereas, covenant is cursed by the Lord, if being defiant and deciphering apostasy. On the whole, the components of Deuteronomistic history emphasize the theology that explains the principles following which humans can gain boons and blessings from God and deciphering non-abidance to the God become liable for His curse (Tanner, â€Å"The Deuteronomistic History†). Deuteronomistic history is theologically said to be the book of ‘heart and instructions’ rather than a narration of laws. This book provides a spiritual insight about the life that an individual needs to live by following God’s directed ways, with firm beliefs in order to get His love and blessings. The most important feature of this particular book is the ‘Homiletical Style’. In this context, the book revolves around the covenants’ c ultural way of expressing relationship between the God and His people. Thus, it can be mentioned that the book develops the idea that a covenant receives blessings by complying with God’s instructions being obedient and truthful, while receives curse and death by disobeying God’s faith and laws (Tanner, â€Å"The Deuteronomistic History†). 2. Compare and Contrast the Three Models of the Conquest: In Deuteronomy, the ‘book of Joshua’ signifies about the three different models applied by Israelites in conquering the ‘land of Canaan’. The origin of Israel in the Canaan was accomplished by implementing influential conquering models, viz. Conquest, Immigration and Revolt model. The immigration model signifies the findings of the German scholars who developed a model of conquest that was different from surface reading of the ‘book of Joshua’. This model also argued that geography has substantial implications on the events occurri ng within a region, as was the case in Israel. The immigration model further proposes that the Israelites first conquered the highlands and then extended their conquest over the plains. Biblical accounts in accordance with the conquest model further reflected that the initial phase of Israelites’ conquest was Trans-Jordan before they crossed the river. The biblical evidences of the conquest model relate a sharp contrast with the perception of Immigration model in this context, where motives are rendered primary significance as the stimulator of events registered in the then period. Unlike the immigration and the conquest model, the revolt model of conquest discusses about Israel’s social revolution within Canaan as her initial origin of conquest, which contrasts the view presented in the other two models (Newberry and Hasan, â€Å"Joshua: The Conquest of Canaan†). 3. Describe the Theologically Correct Ideals of the Ban and the Holy War in Deut.20:1-18 and In Jos h.6:1-27: Deuteronomy 20:1-18 mainly discusses about war. In this context, it has been mentioned that God prepares His covenants, i.e. Israelites, to fight against their enemies and also supports throughout by giving His blessings to victory. This war has been termed as ‘The Holy War’, the reason being the God himself is going with the warriors to fight against the enemy clan and to impart victory to the Israelites. Furthermore,